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Having been diagnosed with lung cancer for 4 years, I have learned a valuable lesson at the cost of my life: if you miss this opportunity, recurrence and metastasis will follow you everywhere

时间:2026-04-15 人气:
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"It's been completely removed, why is it still metastasizing?"


This is the heart-wrenching question asked by countless cancer patients after experiencing recurrence and metastasis. Ms. Wang also went through such a process. In 2020, she was diagnosed with lung cancer due to coughing. After successfully completing surgery and chemotherapy, Ms. Wang thought everything had settled down. However, one and a half years after surgery, she developed abdominal metastasis. Having undergone two major surgeries and the torture of chemotherapy, she once despaired.



Although surgery removed visible tumors, it could not eliminate residual cancer cells. Ms. Wang's experience is precisely due to the neglect of immune vulnerabilities during the postoperative window period.      



01              

             

             
Disease Overview              

Overview of the illness


September 2020: The patient presented with cough and shortness of breath, and was diagnosed with non-small cell lung cancer via bronchoscopy. Immediately after, the patient underwent radical surgery for lung cancer. Postoperative pathology: Considered as intestinal adenocarcinoma with vascular tumor thrombus and lymph node metastasis, followed by four courses of chemotherapy.      

     
July 2022: Only 1.5 years after surgery, a chest and abdominal CT scan revealed multiple enlarged lymph nodes on the lesser curvature of the stomach and in the retroperitoneum, with the most prominent node located at the lesser curvature of the stomach (approximately 17x12mm in size), showing enlargement compared to previous scans and the presence of necrotic areas. Metastasis was considered. A second surgical resection was performed to remove the abdominal lesions. Postoperative pathology revealed metastatic adenocarcinoma in lymph nodes, specifically in groups 1, 3, and 7 (1/5), as well as in the para-aortic lymph nodes (1/1).      



Key turning point: Before fully recovering from the first radical surgery for lung cancer, Ms. Wang, 60 years old, underwent exploratory laparotomy to remove metastatic tumors. These two major surgeries have severely damaged her body, and she would not be able to withstand the surgical trauma if metastasis occurs again.      

     
Lehe's Second Diagnosis and Treatment Suggestions

After abdominal cavity metastasis, Ms. Wang learned about Professor Zhang Minghui's vNKT cell immunotherapy at Tsinghua University through a patient support group. After evaluation, the Lehe New Medical team provided the following second diagnosis and treatment recommendations:


1. The pathology of the first radical resection for lung cancer had already planted hidden dangers - vascular tumor thrombus and lymph node metastasis indicating a risk of systemic micro-metastasis; coupled with the continuous impact of postoperative chemotherapy on the immune system, these factors collectively led to the explosive progression of abdominal cavity metastasis.      

     
2. Despite the removal of visible lesions in the abdominal cavity during the second surgery, multiple sets of lymph node metastases (group 1/3/7 1/5, para-aortic 1/1) remain like ticking time bombs. At this point, due to surgical trauma, the patient's immune function is severely compromised, making it difficult for them to tolerate the combined harm of chemotherapy and radiotherapy.      

     
3. At this time, timely follow-up with vNKT cell therapy can eliminate residual cancer cells, activate the immune system, and effectively reduce the risk of recurrence and metastasis.      

     
4. As natural immune cells with fewer side effects, vNKT cells are not only the optimal solution for controlling tumors but also a crucial turning point for achieving long-term tumor-bearing survival for patients like Ms. Wang with weak immune systems.      

     
Therefore, Ms. Wang initiated vNKT therapy (one course per month) in October 2022 and has completed 26 courses to date. Imaging studies showed no new metastasis, and her survival period has exceeded four years, with her physical strength restored to a level allowing her to engage in daily activities.      


vNKT cell immunotherapy              


NKT cells (Natural killer T cells), are a special T cell subset with both T cell receptor (TCR) and NK cell receptor on their surface. They possess important characteristics of both NK cells and T cells, with the dual ability to recognize tumor cells nonspecifically and specifically, and can rapidly kill tumor cells. Among the NKT cell subsets, there is a larger and more potent special type of soldier discovered by the experimental team led by Professor Zhang Minghui of Tsinghua University, namely vNKT (Variant Natural Killer T) cells.


The population of vNKT cells in the body is very small and they are not easily activated. However, once activated, they can defeat numerous tumor cells that may remain undetected in the body. Additionally, research has found that vNKT cells exhibit dual anti-tumor effects. Not only can they directly kill cancer cells, but they can also regulate the immune microenvironment within tumor tissues, kill inhibitory immune cells known as MDSCs, break down tumor immune evasion, rebuild the normal immune system, and further prevent recurrence and metastasis.              

Experimental conditions: In the presence of vNKT cells, after 16 hours, nearly all B16 tumor cells were killed!


02            

             

             

Imaging changes 

Imaging  changes            
     


On March 16, 2022, an abdominal CT scan revealed suspicious small lymph nodes in the lesser curvature of the stomach, measuring approximately 1.3x0.9cm in size;      

     
On June 30, 2022, a follow-up examination revealed that the gastric lesser curvature lymph nodes had enlarged compared to previous findings, measuring approximately 1.7x1.2cm in size, and showed areas of necrosis, suggesting metastasis;      

     
On July 11, 2022, a follow-up examination revealed that the lymph nodes in the lesser curvature of the stomach showed no significant change compared to June 30, 2022, suggesting the possibility of metastatic tumors;      

     
From October 12, 2022, to March 8, 2024, a follow-up examination was conducted. Compared to the results on July 11, 2022, no significant changes were observed. Please pay attention to the follow-up examination.      

     

The chest CT scan on October 22, 2020, revealed a rounded consolidation shadow with associated streaks in the left lower lung (4.8x4.0cm);


The follow-up examination on November 9, 2020 showed a round solid lesion with a stripe in the left lower lung (4.6x3.8cm);

     
From March 16, 2022, to March 8, 2024, follow-up examinations showed changes post-left lower lung lobectomy, with no signs of metastasis in the chest.



04            

             

       

Conclusion and Review< H83>

Conclusion and Commentary            
What else can we do after the surgery?
After experiencing recurrence and metastasis, Ms. Wang and her family found that her treatment could have avoided many detours.

       
Fighting cancer is not about passively receiving treatment, but actively managing risks. Instead of waiting for recurrence in worry and fear, it's better to hold the decision-making power of your life in your own hands.        

       

Don't let the illusion of recovery become a breeding ground for relapse!



Professor Zhang Minghui pointed out that the best time for Ms. Wang to receive vNKT treatment is after her first surgery. At this time, the tumor burden is at its lowest, but the lymphocytes (such as vNKT and CD8+ T cells) in the bloodstream have been significantly reduced due to surgery and chemotherapy, causing the immune system to be in a "paralyzed" state. Cancer cells that have broken through into the bloodstream and lymph nodes take the opportunity to metastasize. If Ms. Wang receives timely treatment after her first surgery, she can reduce the risk of recurrence and avoid a second surgery.


    
Under traditional treatment, the 5-year survival rate for lung adenocarcinoma with lymph node metastasis is approximately 50%. Ms. Wang has been relapse-free for 4 years post-surgery, and her physical strength, infection frequency, and other indicators have improved, confirming the long-term benefits of immunotherapy.

       
She spent 4 years verifying a truth: Cancer treatment is never just about cutting it out. Surgery is the starting point, while immune reconstruction is the end goal.




On the road to fighting cancer, you are not alone

         
Lehehuanyou Group: This is a communication and interaction platform specially built for patients. Here, everyone shares treatment experiences, disease knowledge, exchanges ideas, helps each other, and works together to overcome the illness.        

       
This is not only a community full of positive energy, where members support each other and provide mutual encouragement, but also a warm haven. The topics discussed among patients here are not only about their illnesses, but also about blessings, greetings, joyful news shared, and even some interesting stories, encouragement, and comfort in life.        

       
Join the Lehe Patient and Friend Group, and embark on a journey of warmth!



       
         
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Zhang Minghui

Founder of Lehe New Medicine


         

Professor Zhang Minghui, who holds a PhD in Immunology from Tsinghua University School of Medicine, has led a research team for over 20 years since the discovery of vNKT cells in 2002. They have accumulated experience in treating over 700 cases of solid tumors, covering almost all common solid tumors. The research results fully demonstrate the great value of vNKT cells in the treatment of solid tumors.



It is suitable for patients with high pathological malignancy or a risk of recurrence after surgery; patients whose tumors have been basically controlled but not cured through conventional treatments such as chemotherapy, radiotherapy, and targeted therapy; patients with persistent high carcinogenic factors; and patients who are intolerant to radiotherapy and chemotherapy. If these patients do not receive effective follow-up treatment after traditional anti-tumor therapy, recurrence, metastasis, or reoccurrence of tumors will be highly probable. In this case, vNKT cell therapy is an ideal follow-up treatment method that can significantly improve patient prognosis.




Written by: Yizhi Tuan      
Reviewed by: Qiao Jiacheng, Wang Ying, Gao Chen      
Edited/typeset by Zhang Jiao      

   

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