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Intestine Cancer

Using case studies, we will guide you to understand the early symptoms of colon cancer

时间:2026-04-22 人气:

If you cannot understand the subsequent professional descriptions, you can finish reading this text in two minutes.

Disease Overview


 
In July 2020, Ms. Huang experienced the defecation of mucous blood, which was deep red, without any apparent cause. A colonoscopy conducted at a local hospital revealed a space-occupying lesion in the sigmoid colon with unclear boundaries. To further clarify the diagnosis, Ms. Huang underwent an abdominal CT scan in August 2020, which showed thickening and enhancement of the sigmoid colon wall, with a possible malignancy (MT) pending further investigation; localized thickening of the rectal wall; scattered small nodules near the uterus; and multiple small lymph nodes beside the bilateral iliac vessels.
After combining the results from the colonoscopy and imaging, a high suspicion of colon cancer was made. Subsequently, a radical resection of the sigmoid colon cancer was performed under general anesthesia. Postoperative pathology revealed adenocarcinoma; histological grading: moderately differentiated with deep invasion, involving the deep muscular layer and adjacent organs , with no histological evidence of intravascular thrombus; and no nerve invasion (-).
After surgery, Ms. Huang underwent a chest CT scan, which revealed a small nodule in the middle lobe of the right lung; strip-like shadows in the lower lobes of both lungs; all tumor markers were within the normal range; and no abnormalities were found in the abdominal CT scan.
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Early Clinical Manifestations of Colon Cancer

Colon cancer is a common malignant tumor of the digestive tract, and the most obvious symptom in its early stage is the presence of blood in the stool. However, blood in the stool is commonly seen in various digestive tract diseases. When blood in the stool occurs, it is necessary to distinguish it and not to panic immediately. There are several types of blood in the stool. When the blood is dark in color, it usually indicates upper gastrointestinal bleeding, such as bleeding from gastric ulcers or gastric cancer, which appears as black "tarry stool." In this case, a gastroscopy should be performed to confirm the diagnosis. When the blood in the stool is bright red, it indicates that the bleeding site is in the lower gastrointestinal tract, specifically the rectum and colon. The feces in the colon are mostly formed and do not undergo significant changes, so the blood in the stool caused by colon cancer is mainly located on the surface of the stool. Since the blood in the stool caused by colon cancer is mostly due to the stimulation of the colon cancer by stool, leading to rupture and bleeding on the tumor surface, patients may also experience abdominal pain at this time.

In addition to rectal and colon cancer, hemorrhoids can also cause bright red blood in the stool. The characteristic of blood in stool caused by hemorrhoids is that the feces and blood do not mix, and the feces are discharged along with the blood, which is very similar to rectal and colon tumors and requires further confirmation with colonoscopy.

Even after undergoing surgery, Ms. Huang was still worried that the tumor might recur, so she sought the help of Professor Zhang Minghui's NKT treatment team at Tsinghua University School of Medicine. After carefully reviewing the displayed cases of NKT cell therapy, she particularly hoped to try it to reduce the risk of tumor recurrence.
After reviewing Ms. Huang's medical records, Professor Zhang Minghui made the following analysis and judgment:

1. The patient was diagnosed with colon cancer in 2020 and underwent surgical treatment.

2. Currently, imaging examinations show no clear signs of tumor recurrence or space occupation. However, this does not necessarily mean the patient has passed the critical stage for malignant tumors. Although no nerve invasion was detected, the tumor has infiltrated to the deep muscular layer and invaded adjacent organs. Histologically, it is impossible to determine the presence of intravascular cancer thrombus, indicating a high risk of future metastasis.

3. NKT therapy utilizes powerful immune cells to eliminate tumor cells that may remain undetected in the body, with essentially no side effects. Combining NKT cell therapy after surgical treatment can effectively reduce the risk of tumor recurrence.

From January 2022 to July 2022, Ms. Huang completed the first phase of treatment. During this follow-up examination, no clear signs of tumor recurrence were observed, and her overall condition remained stable.


 

Imaging

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Tumor marker status: Two follow-up tests in June 2021 and July 2022 showed that the tumor markers CEA, CA125, and CA199 were all within the normal range. Regular follow-up tests are recommended.


 

 Conclusion and Comments


 
Within six months, Ms. Huang completed the first stage of treatment, and no clear signs of tumor recurrence were observed during this follow-up review. Overall, her condition is stable. Ms. Huang self-reported normal life and work; The skin tone has changed from dull, yellowish, and dull to fair and translucent, and I feel more energetic in doing things than before; The frequency of colds and fevers in spring and winter has decreased compared to the past. The quality of life score is 92 points (previously 87 points).
Stage II colon cancer is a common type of colon cancer staging, with five-year survival rates ranging from 87% to 58%. Compared with stage IIIA, the five-year survival rates of stage IIB and IIC are actually worse, indicating that deep penetration of the intestinal wall may be a worse prognostic factor than limited lymph node involvement.
Ms. Huang completed radical surgical treatment, but postoperative pathological results showed that the tumor had a large extent of involvement and still had a risk of recurrence. NKT cell immunotherapy played an indispensable role in reducing the risk of recurrence and metastasis. It not only eliminated residual tumor cells, but also strengthened the immune system, thereby providing long-term stability for patients.
Popular science knowledge is for reference only, individual patients should seek clinical treatment accordingly.   
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【1】 O'Connell J.B., Maggard M.A., Ko C.Y. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst. 2004; 96:1420–1425.

【2】Amin M.B., Edge S., Greene F., editors. AJCC Cancer Staging Manual. 8th ed. Springer International Publishing; New York: 2017.

【3】Swanson R.S., Compton C.C., Stewart A.K., Bland K.I. The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann Surg Oncol. 2003; 10:65–71.

【4】Taieb J, Karoui M, Basile D. How I treat stage II colon cancer patients. ESMO Open. 2021 Aug; 6 (4): 100184. doi: 10.1016/j.emoop.2021.100184. Epub 2021 July 5.

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