No recurrence for 10 years after gastric cancer surgery: A real case reveals the treatment focus behind tumor recurrence

Under the immense pressure of Ms. Liu and her family feeling hopeless and anxious about recurrence and metastasis every day, Professor Zhang Minghui's team from Tsinghua University Immunology took over Ms. Liu's request for help.

After a comprehensive analysis of Ms. Liu's condition, Professor Zhang Minghui's Lehe New Medical Team believes that:< H35>

1、 Ms. LiuMultiple indications suggest a high risk of recurrence and metastasis after surgery;

2、 ChemotherapyOccurrenceAdverse reactions such as bone marrow suppression and neurotoxicity force patients to interrupt treatment,Increased risk of recurrence;

3、 Early treatment severely damages the immune system and weakens the body."Natural protective barrier".

For subsequent treatment measures, targeting high-risk factors such as lymph node metastasis, moderate-to-poorly differentiated adenocarcinoma, it is optimal to strengthen immune monitoring and eliminate micrometastasis, while also considering low side effects, Therefore,Professor Zhang Minghui's Lehe New Medical Team customized a vNKTcell immunotherapy treatment planfor Ms. Liu, starting treatment from March 20163.

       

       

vNKT cell immunotherapy          

NKT cells (Natural killer T cells) are a special T-cell subset with both T-cell receptor (TCR) and NK cell receptors on their surface. They possess important characteristics of both NK cells and T cells, with the dual ability to recognize tumor cells nonspecifically and specifically, and can rapidly kill tumor cells. Among the NKT cell subsets, there is a larger and more potent special type of NKT cell, discovered by the experimental team led by Professor Zhang Minghui of Tsinghua University, known as vNKT (Variant Natural Killer T) cells.

The number of these vNKT cells in the body is very small, and they are not easily activated. However, once activated, they can defeat hundreds of times their number and eliminate tumor cells that may remain undetected in the body. In addition, research has also found that vNKT cells have dual anti-tumor effects. Not only can they directly kill cancer cells, but they can also regulate the immune microenvironment within tumor tissues, kill inhibitory immune cells such as myeloid-derived suppressor cells (MDSCs), break tumor immune escape, rebuild the normal immune system, and further prevent recurrence and metastasis.

         

Experimental conditions: In the presence of vNKT cells, nearly all B16 tumor cells were killed after 16 hours!

Myelosuppression is not uncommon in chemotherapy patients. The results of China's first large-scale survey on myelosuppression data, involving over 10,000 participants and initiated by the Clinical Oncology and Chemotherapy Professional Committee of the Chinese Anti-Cancer Association, show that currently the incidence of myelosuppression in chemotherapy patients in China is as high as 44.2%, with almost one in every two chemotherapy patients experiencing myelosuppression. Approximately 1/3of patients will experience two or more types of blood cell reductions simultaneously^[2].

The occurrence of chemotherapy intolerance does not mean that patients can only passively wait for tumor recurrence and metastasis. Timely follow-up with vNKT cell immunotherapy is the optimal time to reverse tumor recurrence and metastasis. , is 90%New options that are yet unknown to patients with high-risk factors.

Cellular immunotherapy enhances its therapeutic effect through in vitro techniques using autologous or allogeneic immune cells, and then reinfuses them back into the human body to achieve functions such as killing tumor cells. The core of this treatment method is to utilize the natural function of immune cells to effectively eliminate tumor cells that may remain in the body but cannot be detected by existing technical means, thereby effectively preventing tumor recurrence and metastasis.

Cellular immunotherapy also eliminates concerns about drug resistance issues, as immune cells rely on the mobilization of the entire immune system to control tumors after entering the body. Once effective, it is a suppressive “strangling” of cancer cells.

Seeing is believing, hearing is not always true