Lung cancer was found during physical examination. Early intervention can reduce the risk of recurrence and metastasis

With the successive identification of oncogenic driver genes in lung cancer, the classification of lung cancer has been further refined from a simple histopathological classification to a molecular classification based on driver genes. EGFR is commonly found in lung adenocarcinoma.

The EGFR gene is a type of gene that expresses epidermal growth factor receptors, promoting normal cell division and proliferation under physiological conditions. However, in some cases, mutated proto-oncogenes can lead to the development of tumors, with a higher incidence in non-smoking female lung adenocarcinoma. When it was discovered that EGFR mutations often occur in lung adenocarcinoma tumors, people began to consider how to inhibit tumor growth by targeting these mutations. Later, monoclonal antibodies against EGFR, commonly known as "targeted drugs," were developed. Typically, EGFR mutations make lung adenocarcinoma more sensitive to specific targeted drugs.